BiG-SCAPE classes
By default, BiG-SCAPE will try to separate clusters into eight classes. This is done based on the product annotation from antiSMASH. New labels introduced in antiSMASH 5 are annotated with a superscript '5'.
The rules followed are currently:
| antiSMASH annotation | BiG-SCAPE class |
|---|---|
t1pks, T1PKS^5
|
PKS I |
transatpks, t2pks, t3pks, otherks, hglks, transAT-PKS^5, transAT-PKS-like^5, T2PKS^5, T3PKS^5, PKS-like^5, hglE-KS^5 and combinations of these with {t1pks, T1PKS^5} or themselves |
PKS other |
nrps, NRPS^5, NRPS-like^5, thioamide-NRP^5
|
NRPS |
lantipeptide, thiopeptide, bacteriocin, linaridin, cyanobactin, glycocin, LAP, lassopeptide, sactipeptide, bottromycin, head_to_tail, microcin, microviridin, proteusin, lanthipeptide^5, lipolanthine^5, RaS-RiPP^5, fungal-RiPP^5 and combinations of these |
RiPPs |
amglyccycl, oligosaccharide, cf_saccharide, saccharide^5 and combinations of these |
Saccharides |
terpene |
Terpene |
any of {t1pks, T1PKS^5, transatpks, t2pks, t3pks, otherks, hglks, transAT-PKS^5, T2PKS^5, T3PKS^5, PKS-like^5, hglE-KS^5} + any of {nrps, NRPS^5, NRPS-like^5, thioamide-NRP^5} |
PKS/NRPS Hybrids |
acyl_amino_acids, arylpolyene, aminocoumarin, ectoine, butyrolactone, nucleoside, melanin, phosphoglycolipid, phenazine, phosphonate, other, cf_putative, resorcinol, indole, ladderane, PUFA, furan, hserlactone, fused, cf_fatty_acid, siderophore, blactam, fatty_acid^5, PpyS-KS^5, CDPS^5, betalactone^5, PBDE^5, tropodithietic-acid^5, NAGGN^5, halogenated^5 and any combined annotation |
Others |
| * | < mix > |
Hybrids
If the hybrids mode is enabled, some clusters could be analyzed in different classes (if those are valid classes):
If cluster is the PKS-NRP_Hybrids BiG-SCAPE class: the cluster will also be put in the NRPS class and one of the PKS classes (PKS I or PKS other). If the cluster contains the t1pks annotation, it will always be put on the PKS I class.
If the cluster is classified as Others and BiG-SCAPE detects that it's because of a multiple annotation (e.g. terpene-t1pks), BiG-SCAPE will also put the cluster in every different individual class.