BiG-SCAPE classes
By default, BiG-SCAPE will try to separate clusters into eight classes. This is done based on the product
annotation from antiSMASH. New labels introduced in antiSMASH 5 are annotated with a superscript '5'.
The rules followed are currently:
antiSMASH annotation | BiG-SCAPE class |
---|---|
t1pks , T1PKS ^5
|
PKS I |
transatpks , t2pks , t3pks , otherks , hglks , transAT-PKS ^5 , transAT-PKS-like ^5 , T2PKS ^5 , T3PKS ^5 , PKS-like ^5 , hglE-KS ^5 and combinations of these with {t1pks , T1PKS ^5 } or themselves |
PKS other |
nrps , NRPS ^5 , NRPS-like ^5 , thioamide-NRP ^5
|
NRPS |
lantipeptide , thiopeptide , bacteriocin , linaridin , cyanobactin , glycocin , LAP , lassopeptide , sactipeptide , bottromycin , head_to_tail , microcin , microviridin , proteusin , lanthipeptide ^5 , lipolanthine ^5 , RaS-RiPP ^5 , fungal-RiPP ^5 and combinations of these |
RiPPs |
amglyccycl , oligosaccharide , cf_saccharide , saccharide ^5 and combinations of these |
Saccharides |
terpene |
Terpene |
any of {t1pks , T1PKS ^5 , transatpks , t2pks , t3pks , otherks , hglks , transAT-PKS ^5 , T2PKS ^5 , T3PKS ^5 , PKS-like ^5 , hglE-KS ^5 } + any of {nrps , NRPS ^5 , NRPS-like ^5 , thioamide-NRP ^5 } |
PKS/NRPS Hybrids |
acyl_amino_acids , arylpolyene , aminocoumarin , ectoine , butyrolactone , nucleoside , melanin , phosphoglycolipid , phenazine , phosphonate , other , cf_putative , resorcinol , indole , ladderane , PUFA , furan , hserlactone , fused , cf_fatty_acid , siderophore , blactam , fatty_acid ^5 , PpyS-KS ^5 , CDPS ^5 , betalactone ^5 , PBDE ^5 , tropodithietic-acid ^5 , NAGGN ^5 , halogenated ^5 and any combined annotation |
Others |
* | < mix > |
Hybrids
If the hybrids
mode is enabled, some clusters could be analyzed in different classes (if those are valid classes):
If cluster is the PKS-NRP_Hybrids BiG-SCAPE class: the cluster will also be put in the NRPS class and one of the PKS classes (PKS I or PKS other). If the cluster contains the t1pks
annotation, it will always be put on the PKS I class.
If the cluster is classified as Others and BiG-SCAPE detects that it's because of a multiple annotation (e.g. terpene-t1pks
), BiG-SCAPE will also put the cluster in every different individual class.